Why the study?
Does lower body negative pressure modulate vasopressin and renin secretion via cardiac receptors in humans?
Population
14 healthy subjects and 14 age-matched heart-transplant recipients, total n=28.
Comparison
20-minute lower body negative pressure at -15 mm… vs Comparison of physiological responses between…
Authors
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Supports cardiac receptor mediation of vasopressin release; confirms mechanism in humans yet leaves open clinical relevance in transplant recipients.
Does lower body negative pressure modulate vasopressin and renin secretion via cardiac receptors in humans?
This study demonstrates that vasopressin and renin secretion are reflexly modulated by cardiac volume receptors in humans, as these neurohormonal responses to reduced venous return are abolished in denervated heart-transplant recipients.
Giannattasio et al. (1993) studied this question.
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