Key result
Vasopressin infusion nearly doubled the reflex inhibition of renal sympathetic nerve activity associated with increases in LVEDP (slope -11.9 vs -6.2 %/mmHg) mediated through vagal afferents.
Population
13 sinoaortic-denervated anesthetized rabbits
Comparison
Vasopressin infusion (8 mU X kg-1 X min-1) vs Placebo (saline) infusion
Design
Preclinical
Authors
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Hypothesis-generating for vasopressin modulation of vagal volume reflexes in animals; should not yet influence clinical practice.
Absolute Event Rate: -11.9% vs -6.2%
In a rabbit model, vasopressin facilitated the reflex inhibition of renal sympathetic nerve activity associated with increases in LVEDP, an effect mediated through vagal afferents.
Gupta et al. (1987) studied sinoaortic-denervated anesthetized rabbits (n=13). Vasopressin vs. Placebo (saline) was evaluated on Slope relating the percent decrease in renal nerve activity to the rise in left ventricular end-diastolic pressure. Vasopressin infusion nearly doubled the reflex inhibition of renal sympathetic nerve activity associated with increases in LVEDP (slope -11.9 vs -6.2 %/mmHg) mediated through vagal afferents.
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