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December 1, 1987HypertensionOpen Access

Impaired control of vasopressin release in hypertensive subjects with cardiac hypertrophy.

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Why the study?

Does the response of vasopressin, norepinephrine, and renin to lower body negative pressure and propranolol differ between hypertensive subjects with left ventricular hypertrophy and normotensive subjects?

Population

14 subjects: 7 hypertensive subjects with left ventricular hypertrophy and 7 sex-matched and age-matched…

Comparison

Graded lower body negative pressure and… vs Normotensive subjects (control group).

Design

Cross-sectional

Authors

BTBruno TrimarcoGeneral CardiologyNLNicola De LucaFederico II University HospitalASAntonio De SimoneElectrophysiology

Discussion

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Implication

Impaired vasopressin response in LVH hypertension should not yet change practice; leaves open cardiopulmonary receptor role for prospective study.

Structured PICO

Does the response of vasopressin, norepinephrine, and renin to lower body negative pressure and propranolol differ between hypertensive subjects with left ventricular hypertrophy and normotensive subjects?

P
Population
14 subjects: 7 hypertensive subjects with left ventricular hypertrophy and 7 sex-matched and age-matched normotensive subjects.
I
Intervention
Graded lower body negative pressure (-10 and -40 mm Hg) and propranolol administration.
C
Comparator
Normotensive subjects (control group).
O
Outcome
Changes in vascular resistance, right atrial pressure, and plasma levels of vasopressin, norepinephrine, and renin activity.surrogate

Hypertensive patients with left ventricular hypertrophy exhibit impaired control of vasopressin release, likely due to altered cardiopulmonary receptor function.

Cite This Study

Trimarco et al. (1987) studied this question.

synapsesocial.com/papers/6a716f3b35aa2c282ce2bc76https://doi.org/10.1161/01.hyp.10.6.595

Topics

Hypertension management
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Response of vasopressin and norepinephrine to lower body negative pressure in humans1982 · 74 citations
  2. 2Baroreflex control of plasma arginine vasopressin in humans1984 · 26 citations
  3. 3Baroreceptor reflexes in human hypertension.1978 · 163 citations
  4. 4The role of low pressure baroreceptors in reflex vasoconstrictor responses in man1972 · 321 citations
  5. 5Circulatory Responses to Stimulation of Medullated and Non‐medullated Afferents in the Cardiac Nerve in the Cat1973 · 96 citations