Key result
Cardiopulmonary reflex responses were impaired in essential hypertension, especially with left ventricular hypertrophy, but improved markedly following 1 year of therapeutic regression.
Why the study?
Does regression of left ventricular hypertrophy following treatment improve cardiopulmonary reflex regulation in patients with essential hypertension?
Population
32 subjects including 10 normotensive subjects, 10 age-matched essential hypertensive subjects without left…
Comparison
1 year of treatment that induced regression of… vs Normotensive subjects, hypertensive subjects…
Design
Cohort
Follow-up
1 year
Authors
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May support LVH regression to restore reflexes in hypertension; hypothesis-generating and leaves open outcome benefits.
Observational (n=32)
Does regression of left ventricular hypertrophy following treatment improve cardiopulmonary reflex regulation in patients with essential hypertension?
Therapeutic regression of left ventricular hypertrophy in essential hypertension markedly improves impaired cardiopulmonary reflex regulation of peripheral vascular resistance and neurohumoral variables.
Grassı et al. (1988) conducted an observational in Essential hypertension (n=32). Left ventricular hypertrophy and its regression vs. Normotensive subjects and baseline state was evaluated on Changes in forearm vascular resistance, plasma norepinephrine concentration, and plasma renin activity. Cardiopulmonary reflex responses were impaired in essential hypertension, especially with left ventricular hypertrophy, but improved markedly following 1 year of therapeutic regression.
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