Key result
Sex-specific genetic variants and polygenic risk scores were significantly associated with longevity in one sex but not the other, with significant PRS-sex interactions (P=4.8×10−50 to 1.2×10−16).
Population
4,477 participants of Han ethnicity from the Chinese Longitudinal Healthy Longevity Study, including 564…
Design
Case-control
Authors
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Sex-specific genetic longevity signals may refine future risk models; leaves open clinical PRS utility pending replication.
Case-Control (n=4,477)
Yes
p-value: p=2.9 × 10−70 to 1.3 × 10−39
There are remarkable sex differences in genetic associations with longevity, including specific loci and pathways unique to males and females, which may inform individualized health care for the elderly.
Zeng et al. (2018) conducted a case-control in Longevity (n=4,477). Sex-specific genetic variants and polygenic risk scores vs. Opposite sex / Controls was evaluated on Sex-specific loci and pathways associated with longevity (p=2.9 × 10−70 to 1.3 × 10−39). Sex-specific genetic variants and polygenic risk scores were significantly associated with longevity in one sex but not the other, with significant PRS-sex interactions (P=4.8×10−50 to 1.2×10−16).
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