Key result
Midlife elevated blood pressure and cholesterol are important vascular risk factors for the development of Alzheimer's disease in both genders.
Why the study?
Do midlife elevated blood pressure and cholesterol increase the risk of Alzheimer's disease and mild cognitive impairment later in life?
Do midlife elevated blood pressure and cholesterol increase the risk of Alzheimer's disease and mild cognitive impairment later in life?
Effective primary prevention and early treatment of hypertension and hypercholesterolemia may serve as potential avenues for reducing the risk of Alzheimer's disease.
Supports targeting midlife hypertension and hypercholesterolemia to reduce Alzheimer's risk; leaves open need for randomized confirmation.
This review summarizes the main findings from our recent research within the prospective, population‐based study investigating midlife elevated blood pressure (BP) and cholesterol values as risk factors for Alzheimer's disease (AD) and mild cognitive impairment (MCI) later in life. Furthermore, we present some new data on the gender‐related differences in the risk factor profiles for AD. Our results suggest that vascular risk factors are important for the development of AD in both genders, but some gender‐related differences in the risk factors profiles for AD may exist. Our findings also suggest that different environmental factors such as antihypertensive drug treatment may modify the effect of apolipoprotein E ϵ4 allele in the development of AD. These data emphasize the importance of effective primary prevention and early treatment of hypertension and hypercholesterolemia as potential avenues for reducing the risk of AD. Drug Dev. Res. 56:85–94, 2002.
No takes yet. Share an insight, caveat, or question.
Kivipelto et al. (2002) conducted a review in Alzheimer's disease and mild cognitive impairment. Midlife elevated blood pressure and cholesterol was evaluated on Development of Alzheimer's disease and mild cognitive impairment. Midlife elevated blood pressure and cholesterol are important vascular risk factors for the development of Alzheimer's disease in both genders.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: