Key result
Celiac disease is associated with a high prevalence of migraine in both adults and children, and preliminary evidence suggests a gluten-free diet may improve migraine symptoms in affected patients.
Why the study?
Celiac disease presents several extra-intestinal manifestations, and this paper aimed to review the current evidence on the possible association between celiac disease and migraine.
Is there an association between celiac disease and migraine, and does a gluten-free diet improve migraine symptoms in affected patients?
Is there an association between celiac disease and migraine, and does a gluten-free diet improve migraine symptoms in affected patients?
Migraine is a common extra-intestinal manifestation of celiac disease, and a gluten-free diet may offer symptom improvement, though high-quality trials are needed.
CD-migraine link merits consideration in diagnosed patients; leaves open value of routine screening in unselected migraineurs.
Celiac disease (CD) is a common gluten-related enteropathy that presents several extra-intestinal manifestations. Migraine is globally recognized as one of the most diffuse primary headaches. The present paper aims to review the current evidence on the possible association between CD and migraine. Both adults and children having CD exhibit a high prevalence of migraine. However, screening for CD in an unselected population of migraineurs demonstrated contrasting results. Brain imaging may reveal cerebral calcifications and/or white matter abnormalities in a small number of patients having migraine with underlying CD. Limited data are available on the effects of gluten-free diet (GDF) on migraine in the patients affected by CD, suggesting the efficacy of such intervention on the migraine symptoms in both adults and children. Nonetheless, this inference requires verification with high-quality trials conducted with larger sample sizes and longer follow-up periods.
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Gabrielli et al. (2021) conducted a review in Celiac Disease and Migraine. Celiac Disease vs. Controls without Celiac Disease was evaluated. Celiac disease is associated with a high prevalence of migraine in both adults and children, and preliminary evidence suggests a gluten-free diet may improve migraine symptoms in affected patients.
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