Key result
Nonalcoholic fatty liver disease and insulin resistance are closely related conditions that may progress to cirrhosis or diabetes, with ongoing research focusing on their shared pathogenesis.
This review discusses the epidemiological and mechanistic links between nonalcoholic fatty liver disease and insulin resistance, and their progression to diabetes and cirrhosis.
Supports integrated metabolic care in NAFLD; leaves open whether targeting insulin resistance alters progression pending prospective trials.
Nonalcoholic fatty liver disease (NAFLD) is a common disease that is usually accompanied by insulin resistance (IR). Whether or how NAFLD and IR are temporally and mechanistically related is controversial. Recent studies focus on their epidemiology, the importance of dietary fat, the role of adipocytokines and the sterol regulatory element-binding protein-1c. NAFLD and IR may progress to severe diseases, such as cirrhosis, diabetes or both, and understanding the pathogenesis of the precursor conditions has preventive and therapeutic implications. This review focuses on the possible relationships between NAFLD and IR and the treatment options available.
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Grønbæk et al. (2008) conducted a review in Nonalcoholic fatty liver disease and insulin resistance. Nonalcoholic fatty liver disease was evaluated. Nonalcoholic fatty liver disease and insulin resistance are closely related conditions that may progress to cirrhosis or diabetes, with ongoing research focusing on their shared pathogenesis.
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