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September 8, 2026EpilepsiaOpen Access

Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study

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Authors

IZIfrah ZawarARAnny ReyesJHJonathan helm

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Overview

Multicenter cohort study reveals substantial functional decline in older adults with epilepsy, highlighting the need for routine functional assessments.

Key Points

  • To evaluate the prevalence, clinical predictors, and longitudinal progression of instrumental activities of daily living impairment among older individuals with epilepsy.
  • Analyzed 57 adults aged ≥55 years from the multicenter Brain Aging and Cognition in Epilepsy (BrACE) study using the Functional Activities Questionnaire (FAQ), where FAQ ≥ 2 marked mild cognitive impairment (MCI)-level and FAQ ≥ 5 marked dementia-level impairment.
  • Identified cross-sectional predictors with multivariable Firth penalized logistic regression, compared cognitive and quality of life scores, and used exploratory linear regression to track 2-year longitudinal decline.
  • At baseline, 38.6% (n = 22) of participants had MCI-level functional impairment and 17.5% (n = 10) had dementia-level impairment.
  • MCI-level functional impairment was independently associated with early-onset epilepsy (OR = 6.91, 95% CI = 1.36–46.37, p = .019), temporal lobe epilepsy (OR = 3.73, 95% CI = 1.02–16.12, p = .047), and lower education (OR = 0.69, 95% CI = 0.51–0.90, p = .004), while dementia-level impairment was associated only with lower education (OR = 0.62, 95% CI = 0.37–0.87, p = .004).
  • Functionally impaired participants exhibited worse MoCA scores (adjusted-p = .006), reduced verbal memory (adjusted-p = .042), and lower quality of life (adjusted-p = .042), while longitudinal tracking showed 4 of 13 participants declined significantly over 2 years.

Cite This Study

Zawar et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd70a58e84d0ff5b4595bhttps://doi.org/10.1002/epi.70478
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Exploring the relationship between everyday functioning and cognitive performance in individuals with late onset unexplained epilepsy2026
  2. 2Cognitive impairment in older adults with epilepsy: a systematic review2026 · 1 citations
  3. 3Assessing cognition and quality of life in people with epilepsy: A feasibility study for mild and marked cognitive impairment2026
  4. 4Risk Factors Associated With Late-Onset Epilepsy in Dementia and Mild Cognitive Impairment2025 · 22 citations
  5. 5Comparing the associations between performance-based, participant-reported, and study partner-reported instrumental activities of daily living tasks and cognition in cognitively unimpaired adults2026