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June 28, 2026Epilepsia

Exploring the relationship between everyday functioning and cognitive performance in individuals with late onset unexplained epilepsy

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Authors

NCNour Abi ChakraAHAlexis HankersonGMGad A. Marshall

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Overview

Cross-sectional study evaluates cognitive and epilepsy-related factors affecting functional impairment in late onset unexplained epilepsy.

Key Points

  • This research aims to identify determinants of functional impairment in individuals with late onset unexplained epilepsy.
  • Cross-sectional study involving adults with unexplained seizures after age 55
  • Functional Activities Questionnaire (FAQ) used to assess functional impairment
  • Firth penalized logistic regression analyzed predictors of functional impairment.
  • 12.2% of participants exhibited functional impairment.
  • Increased functional impairment was linked to higher antiseizure medication use (OR = 2.74, 95% CI = 1.31–6.74).
  • Lower delayed verbal recall z-score was associated with greater odds of functional impairment (OR = 0.37, 95% CI = 0.14–0.69).

Cite This Study

Chakra et al. (2026) studied this question.

synapsesocial.com/papers/6a40bb4561bb0a67205c6e7bhttps://doi.org/10.1002/epi.70357
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Between Epilepsy and Neurodegeneration: The Hidden Architecture of Late-Onset Unexplained Epilepsy2026
  2. 2Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study2026
  3. 3Late‐onset epilepsy of unknown etiology is more treatment‐responsive than acquired lesional late‐onset epilepsy2025 · 2 citations
  4. 4Late‐onset unexplained epilepsy as a risk factor for cognitive impairment and dementia: Protocol for a multi‐center prospective longitudinal observational study ( <scp>ELUCID</scp> )2025 · 2 citations
  5. 5Sleep disturbances are common in late‐onset epilepsy of unknown origin2026