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June 20, 2026Aging and Health ResearchOpen Access

Cognitive impairment in older adults with epilepsy: a systematic review

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Authors

YFYilin FanXZXiaowen ZhouYCYiling Chen

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Overview

Systematic review summarizes cognitive decline and its associated factors in older adults with epilepsy, highlighting care needs.

Key Points

  • This review aims to summarize cognitive comorbidities and identify factors associated with cognitive impairment in older adults with epilepsy.
  • Systematic review of articles from PubMed, Web of Science, and EMBASE published from November 12, 2019 to November 12, 2025.
  • Total of 62 articles were included following PRISMA guidelines, focusing on cognitive performance in older adults with epilepsy.
  • Data on cognitive impairment rates and associated factors were analyzed from the selected studies.
  • Median cognitive impairment rate in older adults with epilepsy was 51.6% (25.9∼87%).
  • Memory impairment was observed in 31.5% (29.3∼44.0%), language in 38% (15.0∼39.8%), and executive functions in 35.0% (25.0∼41.0%).
  • Older adults with epilepsy were 2.5 times more likely to develop dementia compared to controls, affecting their overall health outcomes.

Cite This Study

Fan et al. (2026) studied this question.

synapsesocial.com/papers/6a362d9ddb0793dc1a535cfchttps://doi.org/10.1016/j.ahr.2026.100288
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Influence of comorbid anxiety and depression disorder on cognition in older adults with epilepsy2025
  2. 2Somatic Comorbidities in Older People Ageing with Epilepsy2026
  3. 3Instrumental activities of daily living in older adults with epilepsy: A cross‐sectional and longitudinal multicenter study2026
  4. 4Bridging Epilepsy and Cognitive Impairment: Insights from EEG and Clinical Observations in a Retrospective Case Series2025
  5. 5EEG features in late-onset epilepsy: possible correlation with cognitive impairment2026