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June 28, 2026Epiliepsy currents/Epilepsy currentsOpen Access

Between Epilepsy and Neurodegeneration: The Hidden Architecture of Late-Onset Unexplained Epilepsy

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Authors

IZIfrah Zawar

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Overview

Randomized trial quantifies brain changes in late-onset unexplained epilepsy, indicating cognitive impacts.

Key Points

  • This research aimed to quantify brain changes in late-onset unexplained epilepsy and examine their associations with cognitive performance.
  • Prospectively recruited 59 patients with LOUE and 53 healthy older adults for comparison.
  • Participants underwent 3T structural MRI to assess cortical thickness and gray matter volumes.
  • Correlations between structural changes and cognitive measures were analyzed using linear models.
  • LOUE patients exhibited reduced cortical thickness in sensory and mesiotemporal areas (d = -0.75, P < .05).
  • Significant reductions in deep gray matter volumes were found in the pallidum and putamen (d = -0.55, P < .05).
  • Correlations were observed between brain structural changes and lower cognitive performance on category fluency (r = 0.31, P = .016).

Cite This Study

Ifrah Zawar (2026) studied this question.

synapsesocial.com/papers/6a40bb4561bb0a67205c6e7ahttps://doi.org/10.1177/15357597261464351
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