What does this research mean for the field?

Liver stiffness is an effective diagnostic and prognostic marker for hepatic involvement in AL amyloidosis, with a threshold of 13.6 kPa indicating involvement and a >50% decrease indicating hepatic recovery. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To evaluate liver stiffness at diagnosis and assess its longitudinal changes during follow-up for diagnosing and monitoring hepatic involvement in AL amyloidosis.

September 8, 2026Amyloid

Liver stiffness in AL amyloidosis: interest in diagnosis and prognosis

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Authors

PCPaul Carrier VLV. Loustaud‐Ratti JCJean-François Cadranel

Discussion

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Overview

Cohort study reveals liver stiffness tracks organ involvement in AL amyloidosis, suggesting a 13.6 kPa threshold identifies hepatic disease.

Key Points

To evaluate liver stiffness at diagnosis and assess its longitudinal changes during follow-up for diagnosing and monitoring hepatic involvement in AL amyloidosis.
Retrospective multicenter cohort assessing liver stiffness at diagnosis across four groups: liver involvement only (group 1), heart involvement only (group 2), both (group 3), or neither (group 4).
Prospective monocentric cohort evaluating longitudinal changes in liver stiffness over time among 19 treated patients.
Receiver operating characteristic analysis identified an optimal diagnostic liver stiffness cutoff of 13.6 kPa for liver involvement, yielding 92% sensitivity and 71% specificity.
In the prospective cohort of 19 treated patients, median liver stiffness decreased by 91% in group 1, 26% in group 2, 79% in group 3, and 19% in group 4, with a reduction greater than 50% indicating hepatic recovery.

Cite This Study

Carrier et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd76758e84d0ff5b46129 https://doi.org/10.1080/13506129.2026.2725750

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September 8, 2026Amyloid

Liver stiffness in AL amyloidosis: interest in diagnosis and prognosis

View Full Paper

Ask AI

Bookmark

Authors

PCPaul Carrier VLV. Loustaud‐Ratti JCJean-François Cadranel

Discussion

Member takes

Overview

Cohort study reveals liver stiffness tracks organ involvement in AL amyloidosis, suggesting a 13.6 kPa threshold identifies hepatic disease.

Key Points

To evaluate liver stiffness at diagnosis and assess its longitudinal changes during follow-up for diagnosing and monitoring hepatic involvement in AL amyloidosis.
Retrospective multicenter cohort assessing liver stiffness at diagnosis across four groups: liver involvement only (group 1), heart involvement only (group 2), both (group 3), or neither (group 4).
Prospective monocentric cohort evaluating longitudinal changes in liver stiffness over time among 19 treated patients.
Receiver operating characteristic analysis identified an optimal diagnostic liver stiffness cutoff of 13.6 kPa for liver involvement, yielding 92% sensitivity and 71% specificity.
In the prospective cohort of 19 treated patients, median liver stiffness decreased by 91% in group 1, 26% in group 2, 79% in group 3, and 19% in group 4, with a reduction greater than 50% indicating hepatic recovery.

Cite This Study

Carrier et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd76758e84d0ff5b46129 https://doi.org/10.1080/13506129.2026.2725750

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