Optimizing human B cell repertoire analyses to interpret clinical data and design sequential HIV vaccines

This is the authors' abstract. We don't add key points for this paper.

Advances in HIV vaccine development focus on eliciting broadly neutralizing antibodies (bNAbs) through next-generation immunogens. Human trials are testing these candidates for their ability to initiate B cell maturation. This workshop report reviews emerging data and methods for analyzing B cell repertoires, highlighting strategies to streamline these labor-intensive processes. The goal is to enable timely, cost-effective design of sequential immunization regimens that induce potent, protective bNAbs against HIV.