What question did this study set out to answer?

Provide global consensus recommendations for the multidisciplinary diagnosis and management of mucormycosis, addressing clinical differences across international health-care settings.

November 4, 2019The Lancet Infectious DiseasesOpen Access

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

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Authors

OCOliver A. CornelyUniversità Cattolica del Sacro Cuore AAAna Alastruey‐IzquierdoInstituto de Salud Carlos III DADorothee ArenzUniversität Hamburg

Discussion

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Implication

Clinical practice guideline demonstrates standardized multidisciplinary diagnostic and therapeutic protocols for mucormycosis, highlighting the necessity of prompt surgery and high-dose antifungals.

Key Points

Provide global consensus recommendations for the multidisciplinary diagnosis and management of mucormycosis, addressing clinical differences across international health-care settings.
An expert panel representing 33 countries across all United Nations regions systematically analyzed published evidence beginning in January 2018.
Consensus guidance was structured under the European Confederation of Medical Mycology One World One Guideline initiative to evaluate diagnostic, surgical, and antifungal interventions.
Prompt diagnostic imaging to delineate infection extent followed by immediate surgical intervention is strongly recommended upon clinical suspicion.
High-dose liposomal amphotericin B is strongly recommended as first-line therapy, whereas intravenous isavuconazole and posaconazole carry moderate first-line recommendations and strong salvage therapy recommendations.
Amphotericin B deoxycholate is recommended against due to severe toxicity, remaining acceptable only when alternatives are inaccessible in resource-limited settings.

Cite This Study

Cornely et al. (2019) studied this question.

synapsesocial.com/papers/6a9fd76a29d9e05a3f618a4f https://doi.org/10.1016/s1473-3099(19)30312-3

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Implication

Clinical practice guideline demonstrates standardized multidisciplinary diagnostic and therapeutic protocols for mucormycosis, highlighting the necessity of prompt surgery and high-dose antifungals.

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Discussion

Member takes

Implication

Key Points

Cite This Study

Global guideline for the diagnosis and management of mucormycosis: an initiative of the European Confederation of Medical Mycology in cooperation with the Mycoses Study Group Education and Research Consortium

Discussion

Member takes

Implication

Key Points

Cite This Study

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