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September 8, 2026Annals of Hepato-Biliary-Pancreatic SurgeryOpen Access

Incident in-hospital sarcopenia after pancreaticoduodenectomy: A single-center retrospective observational study

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Authors

AMA. MaedaMTMasashi TakaoSTShunji Takashima

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Overview

Observational study finds incident in-hospital sarcopenia in nearly one-third of patients after pancreaticoduodenectomy, highlighting acute muscle loss risks during postoperative recovery.

Key Points

  • To describe operationally defined incident in-hospital sarcopenia following pancreaticoduodenectomy and explore associated preoperative patient characteristics.
  • Retrospective observational study of 49 patients undergoing pancreaticoduodenectomy who did not have sarcopenia preoperatively.
  • Incident in-hospital sarcopenia was operationalized using Asian Working Group for Sarcopenia 2019 criteria across two subcohorts: patients discharged within 30 days and those hospitalized for 30 days or longer assessed at postoperative days 28–35.
  • Exploratory multivariable logistic regression models evaluated preoperative predictors including age, sex, composite body-composition index, and prognostic nutritional index.
  • Operationally defined incident in-hospital sarcopenia occurred in 15 of 49 patients (30.6%) overall, affecting 26.3% in the discharge dataset and 33.3% in the postoperative day 28–35 dataset.
  • Vascular resection was performed in 5 patients (10.2%), with an overall mean operative time of 495.5 ± 85.5 minutes and mean blood loss of 654.8 ± 415.1 mL.
  • Exploratory prediction models demonstrated moderate discrimination with area under the curve values of 0.745 and 0.771, although coefficient estimates were imprecise.

Cite This Study

Maeda et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd77658e84d0ff5b462fbhttps://doi.org/10.14701/ahbps.26-136
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Sarcopenia as a prognostic marker in patients undergoing pancreaticoduodenectomy: an updated meta-analysis2025 · 6 citations
  2. 2Influence of sarcopenia on postoperative complications and long-term survival in pancreatic cancer patients undergone pancreaticoduodenectomy2024 · 4 citations
  3. 3Sarcopenic Obesity Is Associated with High Insulin Resistance and New-Onset Diabetes Following Pancreaticoduodenectomy2026
  4. 4A Prospective Cohort Study Evaluating Impact of Sarcopenia on Hospitalization in Patients on Continuous Ambulatory Peritoneal Dialysis2024 · 2 citations
  5. 5Impact of sarcopenia on postoperative outcomes and recurrence in patients with Crohn disease: A retrospective cohort study2026