Key result
In guinea pig ventricular cardiomyocytes, 1 µM R(-)-efonidipine selectively blocked T-type Ca2+ current by 85% without affecting L-type Ca2+ current.
Effect estimate: 85% inhibition
p-value: p=<0.05
R(-)-efonidipine is a highly selective blocker of the T-type Ca2+ current in native myocardium, providing a specific pharmacological tool for T-type channel research.
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No clinical implications yet; leaves open validation of selective T-type blockade in human myocardium.
Tanaka et al. (2004) studied Healthy myocardium (animal model). R(-)-efonidipine vs. Vehicle control was evaluated on Inhibition of T-type Ca2+ current (85% inhibition, p=<0.05). In guinea pig ventricular cardiomyocytes, 1 µM R(-)-efonidipine selectively blocked T-type Ca2+ current by 85% without affecting L-type Ca2+ current.
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