Key result
Concomitant administration of fluoxetine and tramadol in a 27-year-old female with acute transverse myelitis resulted in serotonin syndrome, which resolved rapidly upon discontinuation.
Case Report (n=1)
Concomitant use of serotonergic drugs such as fluoxetine and tramadol can precipitate serotonin syndrome, which resolves upon prompt discontinuation of the offending agents.
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Cautions against fluoxetine-tramadol co-use due to serotonin syndrome; extends known interaction to transverse myelitis but leaves generalizability open.
Pei-Chun Hsieh (2011) conducted a case report in Serotonin syndrome in acute transverse myelitis (n=1). Fluoxetine and tramadol was evaluated on Development and resolution of serotonin syndrome symptoms. Concomitant administration of fluoxetine and tramadol in a 27-year-old female with acute transverse myelitis resulted in serotonin syndrome, which resolved rapidly upon discontinuation.
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