Key result
Causative agent withdrawal and IV fluids effectively control symptoms in a case of serotonin syndrome.
Case Report (n=1)
No
This case demonstrates the critical importance of thorough history-taking and reassessment of provisional diagnoses when initial treatments prove ineffective in identifying serotonin syndrome.
May inform supportive care in serotonin syndrome; leaves open need for prospective trials to guide practice.
Serotonin syndrome is characterised by high levels of serotonin, a neurotransmitter in the nervous system. A 36-year-old male was hospitalised due to generalised weakness, loss of appetite, jaundice, abdominal pain, recurrent fever and delirium. Diagnoses of serotonin syndrome, peptic ulcer disease and metabolic-associated fatty liver disease (MAFLD) were confirmed. Management required withdrawal of the causative agent and administration of intravenous fluid support and benzodiazepines to control agitation and neuromuscular symptoms. This case clearly demonstrates the critical importance of thorough history-taking, careful clinical examination and reassessment of provisional diagnoses when initial treatments prove ineffective.
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Alshmandi et al. (2025) conducted a case report in Serotonin syndrome (n=1). Sertraline and tramadol was evaluated on Symptom resolution. Discontinuation of the offending serotonergic agents and administration of cyproheptadine, lorazepam, and supportive care resulted in complete resolution of serotonin syndrome symptoms within 48 hours.
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