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September 8, 2026Beni-Suef University Journal of Basic and Applied SciencesOpen Access

Protective mechanisms of the brown alga Cystoseira myrica supplementation against testicular alterations in streptozotocin-induced diabetic rats

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Authors

DADoaa A. AliTaibah University

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Overview

Animal study demonstrates that Cystoseira myrica mitigates testicular injury and oxidative stress in diabetic rats, highlighting its therapeutic potential for male fertility.

Key Points

  • To evaluate the protective mechanisms of dietary Cystoseira myrica brown alga supplementation against testicular damage and reproductive dysfunction in streptozotocin-induced diabetic rats.
  • Diabetes was induced in male rats using a single intraperitoneal injection of streptozotocin (STZ).
  • Rats received a diet supplemented with 2% Cystoseira myrica concurrently for 60 days.
  • Serum hormones, antioxidant biomarkers, testicular histology, apoptotic markers (dual staining), and immunohistochemical expression of PCNA, Bcl-2, and Bax were assessed.
  • Cystoseira myrica supplementation significantly increased serum testosterone, superoxide dismutase (SOD), and catalase (CAT) activities while significantly reducing malondialdehyde (MDA) levels compared to untreated diabetic rats.
  • Histological and ultrastructural analyses showed preserved seminiferous tubule architecture and protected spermatogenic cell integrity in supplemented diabetic animals.
  • Immunohistochemical profiling revealed significant upregulation of PCNA and anti-apoptotic Bcl-2, alongside marked downregulation of pro-apoptotic Bax and reduced apoptotic spermatogenic cells.

Cite This Study

Doaa A. Ali (2026) studied this question.

synapsesocial.com/papers/6a9fd79b58e84d0ff5b46733https://doi.org/10.1186/s43088-026-00807-1
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