What does this research mean for the field?

Aseptic splenic abscesses can serve as the presenting manifestation of active lupus nephritis and can be successfully treated with prompt drainage combined with immunosuppressive therapy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To report a rare case of a massive sterile splenic abscess presenting as the initial manifestation of active diffuse lupus nephritis.

September 8, 2026Indian journal of clinical medicineOpen Access

Massive Aseptic Splenic Abscess as the Presenting Manifestation of Active Lupus Nephritis: A Case Report

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Authors

TPThotanolla Surya PrakashSri Venkateswara Institute of Medical Sciences

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Implication

Case report demonstrates successful management of a massive aseptic splenic abscess in active lupus nephritis, highlighting the role of drainage and intensive immunosuppression.

Key Points

To report a rare case of a massive sterile splenic abscess presenting as the initial manifestation of active diffuse lupus nephritis.
Clinical and radiologic evaluation of a 25-year-old female with fever, abdominal pain, and edema using abdominal computed tomography.
Ultrasound-guided drainage of the splenic collection alongside microbiological, serological, and histopathological testing via renal biopsy.
Implementation of high-dose methylprednisolone and cyclophosphamide induction followed by mycophenolate mofetil maintenance, with a 6-month clinical follow-up.
Percutaneous aspiration yielded 800 mL of sterile purulent fluid from a 12 × 13 × 10 cm abscess, with serology revealing anti-dsDNA titers >800 IU/mL and renal biopsy confirming Class IV lupus nephritis.
Combination therapy with targeted percutaneous drainage and aggressive immunosuppressive regimens resulted in complete symptom resolution and sustained biochemical remission at 6 months.

Cite This Study

Thotanolla Surya Prakash (2026) studied this question.

synapsesocial.com/papers/6a9fd7ab58e84d0ff5b468df https://doi.org/10.1177/26339447261480511

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Implication

Case report demonstrates successful management of a massive aseptic splenic abscess in active lupus nephritis, highlighting the role of drainage and intensive immunosuppression.

Massive Aseptic Splenic Abscess as the Presenting Manifestation of Active Lupus Nephritis: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

Massive Aseptic Splenic Abscess as the Presenting Manifestation of Active Lupus Nephritis: A Case Report

Discussion

Member takes

Implication

Key Points

Cite This Study

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