Key result
Coupled gating of Cav1.2 channels increases in frequency in hypertensive smooth muscle and in cells expressing a mutant channel associated with Timothy syndrome.
Authors
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May underlie vascular hypercontractility in hypertension and Timothy syndrome; leaves open whether targeting coupled gating offers therapeutic benefit.
Navedo et al. (2010) studied Hypertension and Timothy syndrome (LQT8). Hypertension and Timothy syndrome mutant Cav1.2 channel expression vs. Normal physiological conditions/wild-type channels was evaluated on Coupled gating events of Cav1.2 channels. Coupled gating of Cav1.2 channels increases in frequency in hypertensive smooth muscle and in cells expressing a mutant channel associated with Timothy syndrome.
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