What does this research mean for the field?

A biomimetic mineralized hydrogel loaded with strontium-proanthocyanidins coordination particles accelerates bone defect repair by simultaneously promoting angiogenesis, modulating inflammation, and enhancing osteogenic differentiation. Novelty: ClaimNovelty.NOVEL_FINDING. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To develop and evaluate a multifunctional biomimetic mineralized hydrogel loaded with strontium-proanthocyanidins for resolving impaired vascularization and persistent inflammation in bone defects.

September 8, 2026Regenerative BiomaterialsOpen Access

Biomimetic mineralized hydrogels loaded with strontium-proanthocyanidins coordination particles for bone defect repair

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Authors

FYFengkai YangGuangdong Medical College YXYijian Xie CJChengye JiangNational University of Defense Technology

Discussion

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Implication

Preclinical evaluation demonstrates accelerated bone repair and reduced inflammation in bone defect models, indicating a multifunctional strategy for skeletal tissue engineering.

Key Points

To develop and evaluate a multifunctional biomimetic mineralized hydrogel loaded with strontium-proanthocyanidins for resolving impaired vascularization and persistent inflammation in bone defects.
Synthesized strontium-proanthocyanidins coordination particles (600–900 nm) and incorporated them into a sodium alginate, hydroxyapatite, and glutamate solution.
Fabricated nnGS hydrogels via dual cross-linking with hydroxyapatite and Ca²⁺ to evaluate mechanical compressive strength.
Assessed anti-inflammatory activity, angiogenic promotion, and osteogenesis-related gene expression in vitro and bone regeneration in an in vivo defect model.
Dual cross-linking with hydroxyapatite and Ca²⁺ increased the compressive strength of the resulting nnGS hydrogel by approximately 43-fold.
In vitro release of proanthocyanidins quenched oxidative stress and modulated inflammation, while Sr²⁺ and Ca²⁺ enhanced angiogenesis and osteogenic gene expression.
In vivo implantation of nnGS hydrogels effectively altered the inflammatory microenvironment, stimulated blood vessel formation, and accelerated bone defect repair.

Cite This Study

Yang et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd7c658e84d0ff5b46c9b https://doi.org/10.1093/rb/rbag185

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Implication

Preclinical evaluation demonstrates accelerated bone repair and reduced inflammation in bone defect models, indicating a multifunctional strategy for skeletal tissue engineering.

Biomimetic mineralized hydrogels loaded with strontium-proanthocyanidins coordination particles for bone defect repair

Discussion

Member takes

Implication

Key Points

Cite This Study

Biomimetic mineralized hydrogels loaded with strontium-proanthocyanidins coordination particles for bone defect repair

Discussion

Member takes

Implication

Key Points

Cite This Study

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