Chemical synthesis reveals the formation of an acylhydrazone derivative from strictic acid, indicating potential strategies to engineer plant-derived diterpenoids.
Under the application of a semi-synthesis strategy, an acylhydrazone derivative from strictic acid (SA), a natural neo-clerodane diterpenoid with a unique 5,10-seco skeleton isolated from Schnabelia terniflora, has been synthesized via a two-step synthetic pathway including hydrazide formation from the carboxylic acid moiety of SA and further hydrazonation with p-methylcinnamaldehyde. The target structure was confirmed by 1H NMR, 13C NMR and HRMS data.
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Lang et al. (2026) studied this question.
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