What does this research mean for the field?

Longer duration of diabetes and smoking are consistently associated with worse early postoperative failure-free survival after arthrodesis for Eichenholtz stage III diabetic Charcot neuroarthropathy. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To determine whether routinely available clinical, laboratory, and surgical variables are associated with early postoperative failure-free survival after arthrodesis for diabetic Charcot neuroarthropathy of the foot or ankle.

September 8, 2026Foot & Ankle InternationalOpen Access

Perioperative Factors Associated With Postoperative Failure-Free Survival After Arthrodesis for Diabetic Charcot Neuroarthropathy of the Foot or Ankle

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Authors

QWQiong Wang YZYan Zhang SSShen Shen

Discussion

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Overview

Retrospective cohort study finds diabetes duration and smoking predict surgical failure after arthrodesis for Charcot foot, highlighting critical targets for preoperative risk stratification.

Key Points

To determine whether routinely available clinical, laboratory, and surgical variables are associated with early postoperative failure-free survival after arthrodesis for diabetic Charcot neuroarthropathy of the foot or ankle.
Single-center retrospective exploratory prognostic cohort study screening consecutive surgically treated patients between June 2017 and October 2025.
Enrolled 83 patients with Eichenholtz stage III diabetic Charcot neuroarthropathy of the foot or ankle who underwent arthrodesis and had sufficient follow-up for early outcome ascertainment.
Assessed failure-free survival using Kaplan-Meier analyses, multivariable Cox proportional hazards regression models, and sensitivity analyses adjusting for anatomic variables and prior ulcer history.
Postoperative failure occurred in 35 of 83 patients (42.2%), with estimated overall failure-free survival rates of 96.0% (95% CI, 88.1%-98.7%) at 6 months and 45.3% (95% CI, 31.2%-58.5%) at 12 months.
In primary multivariable Cox regression, longer diabetes duration (adjusted HR 1.091, 95% CI 1.034-1.150; P = .001) and smoking (adjusted HR 2.579, 95% CI 1.119-5.946; P = .026) independently predicted worse failure-free survival.
Glycated hemoglobin was not independently associated with failure-free survival (adjusted HR 1.229, 95% CI 0.972-1.555; P = .085), nor were Brodsky classification or prior ulcer history after adjustment.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd81458e84d0ff5b4743f https://doi.org/10.1177/10711007261473606

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September 8, 2026Foot & Ankle InternationalOpen Access

Perioperative Factors Associated With Postoperative Failure-Free Survival After Arthrodesis for Diabetic Charcot Neuroarthropathy of the Foot or Ankle

View Full Paper

Ask AI

Bookmark

Authors

QWQiong Wang YZYan Zhang SSShen Shen

Discussion

Member takes

Overview

Retrospective cohort study finds diabetes duration and smoking predict surgical failure after arthrodesis for Charcot foot, highlighting critical targets for preoperative risk stratification.

Key Points

To determine whether routinely available clinical, laboratory, and surgical variables are associated with early postoperative failure-free survival after arthrodesis for diabetic Charcot neuroarthropathy of the foot or ankle.
Single-center retrospective exploratory prognostic cohort study screening consecutive surgically treated patients between June 2017 and October 2025.
Enrolled 83 patients with Eichenholtz stage III diabetic Charcot neuroarthropathy of the foot or ankle who underwent arthrodesis and had sufficient follow-up for early outcome ascertainment.
Assessed failure-free survival using Kaplan-Meier analyses, multivariable Cox proportional hazards regression models, and sensitivity analyses adjusting for anatomic variables and prior ulcer history.
Postoperative failure occurred in 35 of 83 patients (42.2%), with estimated overall failure-free survival rates of 96.0% (95% CI, 88.1%-98.7%) at 6 months and 45.3% (95% CI, 31.2%-58.5%) at 12 months.
In primary multivariable Cox regression, longer diabetes duration (adjusted HR 1.091, 95% CI 1.034-1.150; P = .001) and smoking (adjusted HR 2.579, 95% CI 1.119-5.946; P = .026) independently predicted worse failure-free survival.
Glycated hemoglobin was not independently associated with failure-free survival (adjusted HR 1.229, 95% CI 0.972-1.555; P = .085), nor were Brodsky classification or prior ulcer history after adjustment.

Cite This Study

Wang et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd81458e84d0ff5b4743f https://doi.org/10.1177/10711007261473606

View Full Paper

Ask AI

Bookmark