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July 12, 2026Orthopedic ReviewsOpen Access

Beyond Early Complications: Diabetic Neuropathy Is Associated With Progressive Failure, Reoperation, and Mortality After Ankle Arthrodesis

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Authors

THTarek HarhashBJBashar JawichAEAlqasim Elnaggar

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Overview

Retrospective cohort study shows increased complications and mortality in diabetic patients with neuropathy after ankle surgery, highlighting the need for careful planning.

Key Points

  • This study aims to evaluate the impact of diabetic peripheral neuropathy on postoperative outcomes following ankle arthrodesis.
  • Retrospective cohort study using TriNetX Research Network electronic health records from January 2020 to January 2025.
  • Included adult diabetic patients undergoing primary ankle arthrodesis for osteoarthritis, stratified by presence of neuropathy.
  • 731 patients with and without neuropathy were matched for analysis.
  • Patients with diabetic neuropathy had significantly higher rates of postoperative infections and mechanical failures.
  • At long-term follow-up, those with neuropathy experienced greater rates of revision arthrodesis and mortality.
  • Emergency department utilization was also notably higher among patients with neuropathy.

Cite This Study

Harhash et al. (2026) studied this question.

synapsesocial.com/papers/6a5333754f7abc118adee082https://doi.org/10.52965/001c.163931
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Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

  1. 1Diabetic Neuropathy is an Independent Risk Factor for Poor Orthopedic Outcomes Following Operatively Treated Ankle Fractures2025 · 2 citations
  2. 2Do Patients With Insulin-Dependent and Non–Insulin-Dependent Diabetes Have Different Risks for Complications After Total Ankle Arthroplasty?2024 · 3 citations
  3. 3Diabetes Mellitus and Total Ankle Arthroplasty Complications2024 · 5 citations
  4. 4The Influence of Peripheral Artery Disease on Postoperative Complications Following Open Reduction and Internal Fixation for Ankle Fractures2026 · 1 citations
  5. 5Perioperative Factors Associated With Postoperative Failure-Free Survival After Arthrodesis for Diabetic Charcot Neuroarthropathy of the Foot or Ankle2026