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September 8, 2026The Egyptian Journal of Neurology Psychiatry and NeurosurgeryOpen Access

Relapsing-remitting multiple sclerosis understanding the disability-depression connection

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Authors

RHRaghdaa Abdel khalek Abdel HalemMDMarwa Mohamed Mahmoud DahrougMEMohamed Mostafa EL-Hamady

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Overview

Cross-sectional study finds physical disability independently predicts moderate-to-severe depression in relapsing-remitting multiple sclerosis, highlighting the need for targeted mental healthcare.

Key Points

  • To evaluate the association between physical disability severity and depression in patients with relapsing-remitting multiple sclerosis while accounting for neurological symptoms and sociodemographic variables.
  • Conducted a cross-sectional study recruiting 30 patients with relapsing-remitting multiple sclerosis (aged 18–60 years, diagnosed by 2024 Revised McDonald Criteria) and 30 matched healthy controls at a university hospital clinic in Egypt.
  • Administered standardized neuropsychiatric tools including the Expanded Disability Status Scale (EDSS), Beck Depression Inventory-II (BDI-II), and Columbia-Suicide Severity Rating Scale (C-SSRS).
  • Analyzed group differences using parametric and non-parametric tests, and performed multivariate logistic regression to determine independent predictors of moderate-to-severe depression.
  • Moderate to very severe depression affected 73.3% of multiple sclerosis cases compared to 23.3% of healthy controls (P = 0.001).
  • Higher depression severity was significantly linked to elevated EDSS scores (median EDSS: 2 vs. 0, P = 0.013), visual symptoms (P = 0.031), and sensory symptoms (P = 0.046).
  • Multivariate logistic regression revealed EDSS score as an independent predictor of moderate-to-severe depression (OR = 3.869, P = 0.042), whereas sociodemographic factors showed no significant association.

Cite This Study

Halem et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd82058e84d0ff5b47591https://doi.org/10.1186/s41983-026-01228-8
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