What does this research mean for the field?

In early pulmonary sarcoidosis, baseline systemic treatment and Scadding Stage II disease independently predict an increased risk of disease relapse, whereas increasing age is associated with a lower relapse risk. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To identify clinical determinants and independent predictors of relapse-free survival in patients presenting with early-stage pulmonary sarcoidosis.

September 8, 2026Journal of Clinical MedicineOpen Access

Clinical Predictors of Relapse-Free Survival in Early Pulmonary Sarcoidosis

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Authors

FUFatma Işıl UzelKoç University BUBurak UzelINTRASOFT International (Luxembourg)EYEsin YentürkYedikule Teaching Hospital

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Implication

Retrospective cohort study reveals predictors of disease relapse in early pulmonary sarcoidosis, highlighting baseline clinical severity as a key driver of long-term recurrence risk.

Key Points

To identify clinical determinants and independent predictors of relapse-free survival in patients presenting with early-stage pulmonary sarcoidosis.
Retrospective cohort study of 200 adults (mean age 42.0 ± 11.2 years, 72.0% women) with biopsy-confirmed Stage I–II pulmonary sarcoidosis followed for up to 15 years.
The primary endpoint was disease relapse requiring re-initiation or escalation of systemic therapy following remission.
Time to relapse was evaluated using Kaplan–Meier survival analysis, log-rank tests, and multivariable Cox proportional hazards modeling.
Disease relapse occurred in 36 patients (18.0%), with relapse-free survival being significantly lower among individuals who received systemic therapy at baseline than untreated individuals (log-rank p < 0.001).
Multivariable Cox regression identified baseline systemic therapy (adjusted HR 4.27, 95% CI 1.39–13.09; p = 0.011) and Scadding Stage II disease (HR 2.58, 95% CI 1.26–5.29; p = 0.010) as independent predictors of relapse.
Older age was associated with lower relapse hazard (HR 0.70 per 10-year increase, 95% CI 0.50–1.00; p = 0.047), while baseline FVC and sex did not show independent associations.

Cite This Study

Uzel et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd82058e84d0ff5b47634 https://doi.org/10.3390/jcm15176875

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Implication

Retrospective cohort study reveals predictors of disease relapse in early pulmonary sarcoidosis, highlighting baseline clinical severity as a key driver of long-term recurrence risk.

Clinical Predictors of Relapse-Free Survival in Early Pulmonary Sarcoidosis

Discussion

Member takes

Implication

Key Points

Cite This Study

Clinical Predictors of Relapse-Free Survival in Early Pulmonary Sarcoidosis

Discussion

Member takes

Implication

Key Points

Cite This Study

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