What does this research mean for the field?

In patients with alcohol use disorder, thiamine supplementation is associated with a higher adjusted risk of anemia, likely reflecting more severe baseline health conditions, although higher doses may offer long-term protective effects. Novelty: ClaimNovelty.INCREMENTAL. Consensus alignment: ConsensusAlignment.NEUTRAL.

What question did this study set out to answer?

To investigate the association between thiamine therapy and the subsequent risk of developing anemia among patients diagnosed with alcohol use disorder.

September 8, 2026Alcoholism Treatment Quarterly

The Protective Role of Thiamine Supplementation Against Anemia in Patients with Alcohol Use Disorder: A Large-Scale Cohort Analysis

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Authors

PSPin-Sin Shih PLPei‐Yun LinKaohsiung Medical University YLYen-Ju Lin

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Implication

Retrospective cohort study finds higher anemia risk with thiamine therapy in alcohol use disorder, indicating baseline clinical severity precedes dose-dependent long-term protection.

Key Points

To investigate the association between thiamine therapy and the subsequent risk of developing anemia among patients diagnosed with alcohol use disorder.
Conducted a retrospective cohort study using Taiwan's National Health Insurance Research Database (NHIRD) among 9,356 adults aged ≥ 40 years diagnosed with alcohol use disorder between 2000 and 2018.
Categorized patients into thiamine therapy users (≥1 prescription; n = 2,339) and non-users (n = 7,017), analyzing incident anemia via Cox proportional hazards models and stratified cumulative defined daily doses (DDD).
Anemia occurred in 3% of thiamine users versus 2% of non-users (incidence rate: 20.44 vs 40.07 per 1,000 person-years), with thiamine therapy associated with higher adjusted anemia risk overall (aHR 1.46, 95% CI 1.06–2.02; p = .02).
Dose–response analysis demonstrated an aHR of 1.62 (95% CI 1.15–2.28, p < .001) for <23 DDD, 1.23 (95% CI 0.68–2.20, p = .5) for 23–121 DDD, and 0.57 (95% CI 0.14–2.29, p = .43) for >121 DDD.

Cite This Study

Shih et al. (2026) studied this question.

synapsesocial.com/papers/6a9fd82f58e84d0ff5b47885 https://doi.org/10.1080/07347324.2026.2677499

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Implication

Retrospective cohort study finds higher anemia risk with thiamine therapy in alcohol use disorder, indicating baseline clinical severity precedes dose-dependent long-term protection.

The Protective Role of Thiamine Supplementation Against Anemia in Patients with Alcohol Use Disorder: A Large-Scale Cohort Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

The Protective Role of Thiamine Supplementation Against Anemia in Patients with Alcohol Use Disorder: A Large-Scale Cohort Analysis

Discussion

Member takes

Implication

Key Points

Cite This Study

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