What question did this study set out to answer?

To identify and characterize mechanisms of HIV preexposure prophylaxis (PrEP) failure beyond biomedical drug breakthrough in high-risk young Black men who have sex with men.

April 6, 2018Clinical Infectious DiseasesOpen Access

Beyond the Biomedical: Preexposure Prophylaxis Failures in a Cohort of Young Black Men Who Have Sex With Men in Atlanta, Georgia

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Authors

DSDavid P. SerotaUniversity of Miami EREli S. RosenbergOffice of the Assistant Secretary for Health ALAnnie LockardEmory University

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Implication

Cohort study reveals high HIV incidence and behavioral failure typologies in young Black men who have sex with men, highlighting gaps between drug efficacy and real-world effectiveness.

Key Points

To identify and characterize mechanisms of HIV preexposure prophylaxis (PrEP) failure beyond biomedical drug breakthrough in high-risk young Black men who have sex with men.
Prospective cohort study of HIV-negative young Black men who have sex with men in Atlanta, Georgia, provided with access to free PrEP services.
Evaluation of PrEP engagement history and patterns among participants who underwent HIV seroconversion during the study period.
Interim analysis revealed a high annual HIV incidence of 6.2% despite access to free PrEP services.
All 14 participants who seroconverted had been offered PrEP prior to acquiring HIV.
Identified four non-biomedical typologies of PrEP failure alongside biomedical failure: low adherence, discontinuation, contemplation without initiation, and refusal.

Cite This Study

Serota et al. (2018) studied this question.

synapsesocial.com/papers/6a9fd8ad1cf0e01ec7bab767 https://doi.org/10.1093/cid/ciy297

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Implication

Cohort study reveals high HIV incidence and behavioral failure typologies in young Black men who have sex with men, highlighting gaps between drug efficacy and real-world effectiveness.

Beyond the Biomedical: Preexposure Prophylaxis Failures in a Cohort of Young Black Men Who Have Sex With Men in Atlanta, Georgia

Discussion

Member takes

Implication

Key Points

Cite This Study

Beyond the Biomedical: Preexposure Prophylaxis Failures in a Cohort of Young Black Men Who Have Sex With Men in Atlanta, Georgia

Discussion

Member takes

Implication

Key Points

Cite This Study

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