Key result
A 4-month hypocaloric diet significantly increased circulating omentin-1 concentrations from 44.9 to 53.4 ng/ml (p < 0.001) in obese subjects, correlating with improved insulin sensitivity.
Why the study?
Does a hypocaloric diet-induced weight loss increase circulating omentin-1 concentrations in obese subjects?
Cohort (n=35)
No
Does a hypocaloric diet-induced weight loss increase circulating omentin-1 concentrations in obese subjects?
Weight loss induced by a hypocaloric diet significantly increases circulating omentin-1 concentrations, which correlates with improved insulin sensitivity.
Answers are grounded in this paper and cite their sources.
Omentin-1 rise after diet-induced weight loss should not yet change practice; leaves open causal role in insulin sensitivity.
BACKGROUND: Omentin-1 is a novel adipokine expressed in visceral adipose tissue and negatively associated with insulin resistance and obesity. We aimed to study the effects of weight loss-induced improved insulin sensitivity on circulating omentin concentrations. METHODS: Circulating omentin-1 (ELISA) concentration in association with metabolic variables was measured in 35 obese subjects (18 men, 17 women) before and after hypocaloric weight loss. RESULTS: Baseline circulating omentin-1 concentrations correlated negatively with BMI (r = -0.58, p < 0.001), body weight (r = -0.35, p = 0.045), fat mass (r = -0.67, p < 0.001), circulating leptin (r = -0.7, p < 0.001) and fasting insulin (r = -0.37, p = 0.03). Circulating omentin-1 concentration increased significantly after weight loss (from 44.9 +/- 9.02 to 53.41 +/- 8.8 ng/ml, p < 0.001). This increase in circulating omentin after weight loss was associated with improved insulin sensitivity (negatively associated with HOMA value and fasting insulin, r = -0.42, p = 0.02 and r = -0.45, p = 0.01, respectively) and decreased BMI (r = -0.54, p = 0.001). CONCLUSION: As previously described with adiponectin, circulating omentin-1 concentrations increase after weight loss-induced improvement of insulin sensitivity.
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Moreno‐Navarrete et al. (2010) conducted a cohort in Obesity (n=35). Hypocaloric diet vs. Baseline was evaluated on Circulating omentin-1 concentration (p=<0.001). A 4-month hypocaloric diet significantly increased circulating omentin-1 concentrations from 44.9 to 53.4 ng/ml (p < 0.001) in obese subjects, correlating with improved insulin sensitivity.
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