Key result
Women with NAFLD (n=55) had lower serum omentin-1 levels compared to healthy controls (n=40), with the lowest values observed in patients with cirrhosis.
Why the study?
The role of omentin-1, an adipokine with anti-inflammatory effects, in non-alcoholic fatty liver disease (NAFLD) is scarcely investigated.
Are serum omentin-1 levels associated with the severity of NAFLD and cardiovascular risk factors in Egyptian women?
Case-Control (n=95)
Are serum omentin-1 levels associated with the severity of NAFLD and cardiovascular risk factors in Egyptian women?
Serum omentin-1 levels are inversely associated with NAFLD severity and cardiometabolic risk factors in women, suggesting its potential as a noninvasive diagnostic biomarker.
Omentin-1 levels were associated with NAFLD severity in women; hypothesis-generating and requires prospective validation before clinical use.
Background: Non-Alcoholic Fatty Liver Disease (NAFLD) is a pathologic condition with insidious course that varies from simple steatosis to steatohepatitis (NASH) with potential progression to cirrhosis. NAFLD is associated with metabolic syndrome, obesity, diabetes mellitus and insulin resistance. Omentin-1 is an adipokine which possesses anti-inflammatory effects; the role of omentin-1 in NAFLD is scarcely investi-gated.Aim of Study: Our study aimed to evaluate serum omentin-1 levels in women with NAFLD and to assess its relation to the severity of NAFLD and risk factors for cardiovascular morbidities among Egyptian women.Subjects and Methods: Case control study enrolled 55 women biopsy-proven NAFLD and forty healthy volunteers as a control group. NAFLD patients were divided into three groups; simple steatosis (n=30), NASH (n=15), and cirrhosis (n=10). Serum omentin-1 levels were measured using an Enzyme-Linked Immunosorbent Assay (ELISA).Results: Our results revealed that, NAFLD patients had lower values of serum omentin-1 when compared to controls. Among NAFLD patients, patients with cirrhosis had the lowest values of serum omentin-1. We detected significant negative correlations between serum omentin-1 levels and cardiomet-abolic parameters, obesity indices and liver function among patients with NAFLD.Conclusion: Women with NAFLD had lower values of serum omentin-1 than control group; moreover, among NAFLD groups, the lowest values were observed in patients with cirrhosis. The diagnostic power of serum levels of omentin-1 was highly significant thus; it could represent a promising noninvasive diagnostic biomarker of NAFLD.
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RASHAD et al. (2019) conducted a case-control in Nonalcoholic Fatty Liver Disease (NAFLD) (n=95). Nonalcoholic Fatty Liver Disease (NAFLD) vs. Healthy volunteers was evaluated on Serum omentin-1 levels. Women with NAFLD (n=55) had lower serum omentin-1 levels compared to healthy controls (n=40), with the lowest values observed in patients with cirrhosis.
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