Why the study?
Nonalcoholic fatty liver disease is the most common chronic liver condition worldwide and is often associated with Metabolic Syndrome features, but the association between circulating Omentin levels and NAFLD required evaluation.
Are circulating Omentin levels associated with nonalcoholic fatty liver disease?
Are circulating Omentin levels associated with nonalcoholic fatty liver disease?
This meta-analysis found no significant overall association between circulating omentin levels and NAFLD, though subgroup analysis suggested higher levels in studies with larger sample sizes.
No overall omentin-NAFLD association detected; larger studies needed to clarify biomarker role.
BACKGROUND: Nonalcoholic fatty liver disease (NAFLD) is the most common chronic liver condition worldwide. NAFLD is often associated with features of Metabolic Syndrome such as obesity and insulin resistance. METHODS: The current comprehensive meta-analysis was performed to evaluate the association between circulating Omentin levels and NAFLD. A systematic search in Scopus, Web of Science, PubMed, and Google Scholar databases was conducted to identify relevant studies up until 5th May 2022. The standard mean difference (SMD) values and 95% confidence intervals (CIs) were computed for the association of Omentin levels with NAFLD risk in a random effect model. RESULTS: The meta-analysis involved 6 case-control studies with a total of 371 cases and 269 controls. Pooled SMD showed no significant difference in serum Omentin between NAFLD and healthy groups (SMD= -0.047 and 95% CI -0.957_0.862 P=0.91). Subgroup analysis based on sample size showed that the average Omentin levels were significantly higher in NAFLD patients in studies with sample size ≥70 (SMD=0.356 CI 0.056_0.655 P=0.02). CONCLUSION: Additional well-designed studies with more sample sizes are essential to clarify the potential role of Omentin as a risk marker of NAFLD.
No takes yet. Share an insight, caveat, or question.
Khodashahi et al. (2023) studied this question.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: