Key result
In a cohort of 247 ambulatory heart failure patients, the 11 most frequent HLA haplotypes would cover 31.17% of patients in need of allogeneic cell therapy.
Why the study?
Well-characterized cell banks with HLA representative of a given population are needed because obtaining high numbers of autologous cells for cell therapy is difficult.
Cross-Sectional (n=247)
Identifying common HLA haplotypes in heart failure patients can help establish representative cell banks for allogeneic cell therapy, potentially reducing the need for concomitant immunosuppression.
Hypothesis-generating for HLA-matched allogeneic cell therapy donor selection in HF; prospective validation required before clinical use.
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Roura et al. (2019) conducted a cross-sectional in Heart failure (n=247). HLA allele and haplotype frequencies was evaluated on HLA allele and haplotype frequencies. In a cohort of 247 ambulatory heart failure patients, the 11 most frequent HLA haplotypes would cover 31.17% of patients in need of allogeneic cell therapy.
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