Why the study?
Does intravenous diphenylhydantoin affect left ventricular function in patients with heart disease?
Population
9 patients with heart disease undergoing cardiac catheterization
Comparison
Diphenylhydantoin 250 mg administered… vs Baseline
Design
Case_series
Follow-up
30 minutes
Authors
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Transient myocardial effects support monitoring during IV use in heart disease; leaves open safety in larger controlled cohorts.
Does intravenous diphenylhydantoin affect left ventricular function in patients with heart disease?
Intravenous diphenylhydantoin causes a transient, clinically insignificant depression of myocardial function without significant systemic hypotension.
LIEBERSON et al. (1967) studied this question.
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