Key result
Two different pathways for external Ca2+ are used to refill ACh-sensitive internal stores in canine airway smooth muscle: one via a CPA-sensitive Ca2+ pump and another CPA-insensitive pathway.
The study identifies two distinct pathways (one CPA-sensitive active pump and one CPA-insensitive) for refilling ACh-sensitive internal Ca2+ stores in canine airway smooth muscle.
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No immediate clinical implications for human airway disease; leaves open dual Ca2+ refilling pathways as targets for further mechanistic study.
Bourreau et al. (1993) studied this question. Cyclopiazonic acid (CPA) was evaluated on Refilling of ACh-sensitive internal Ca2+ stores. Two different pathways for external Ca2+ are used to refill ACh-sensitive internal stores in canine airway smooth muscle: one via a CPA-sensitive Ca2+ pump and another CPA-insensitive pathway.
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