Key result
Mutations in the S6 transmembrane segment of Shaker potassium channels, particularly Y485C, reduce single channel conductance and maximum open probability, indicating an effect on the activation gate.
Mutations in the cytoplasmic extension of the S6 transmembrane segment of Shaker potassium channels alter single channel conductance and open state stability.
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Findings in Shaker channels should not yet inform clinical decisions; leaves open whether S6 mutations disrupt gating in human Kv channels.
Ding et al. (2002) studied this question. Cysteine substitution in the S6 transmembrane segment (N482 to T489) vs. Wild-type channels was evaluated on Single channel currents and maximum open probability (P(o,max)). Mutations in the S6 transmembrane segment of Shaker potassium channels, particularly Y485C, reduce single channel conductance and maximum open probability, indicating an effect on the activation gate.
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