Key result
Intravenous remifentanil reduced breathlessness unpleasantness and depressed anticipatory activity in the amygdala and hippocampus compared to saline during experimental breathlessness.
Why the study?
Does intravenous remifentanil reduce anticipatory brain responses and breathlessness unpleasantness in healthy volunteers undergoing experimental breathlessness?
RCT
randomised
Does intravenous remifentanil reduce anticipatory brain responses and breathlessness unpleasantness in healthy volunteers undergoing experimental breathlessness?
Low-dose remifentanil reduces breathlessness unpleasantness by altering anticipatory brain activity in the amygdala and hippocampus, suggesting a mechanism for opioid palliation of breathlessness.
Authors
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May support opioid use for refractory dyspnea; extends RCT evidence for limbic modulation of breathlessness anticipation.
Hayen et al. (2017) conducted an RCT in Experimental breathlessness. Remifentanil vs. Saline was evaluated on Anticipatory brain activity and breathlessness unpleasantness. Intravenous remifentanil reduced breathlessness unpleasantness and depressed anticipatory activity in the amygdala and hippocampus compared to saline during experimental breathlessness.
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