What question did this study set out to answer?

To determine whether biosynthetic human insulin produced via recombinant DNA technology shares identical chemical, physical, immunological, and biological characteristics with native pancreatic human insulin and purified pork insulin.

March 1, 1981Diabetes Care

Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin

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Authors

RCRonald E. ChanceEli Lilly (United States)EKEugene P. KroeffUniversity of Iowa JHJ. A. HoffmannUtah State University

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Implication

Comparative laboratory analysis demonstrates structural and functional equivalence between biosynthetic and pancreatic human insulin, highlighting recombinant technology as a viable source.

Key Points

To determine whether biosynthetic human insulin produced via recombinant DNA technology shares identical chemical, physical, immunological, and biological characteristics with native pancreatic human insulin and purified pork insulin.
Subjected recombinant DNA-derived biosynthetic human insulin to a comprehensive battery of analytic laboratory procedures.
Assessed chemical and physical characteristics alongside immunological reactivity.
Compared biologic activity directly against both native pancreatic human insulin and purified pork insulin standards.
Biosynthetic human insulin demonstrated complete chemical, physical, and immunological equivalence to native pancreatic human insulin across analytic testing.
The recombinant product displayed biologic equivalence to both native pancreatic human insulin and purified pork insulin in functional evaluations.

Cite This Study

Chance et al. (1981) studied this question.

synapsesocial.com/papers/6a9fe87bc2a6bb3d9844b037 https://doi.org/10.2337/diacare.4.2.147

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Implication

Comparative laboratory analysis demonstrates structural and functional equivalence between biosynthetic and pancreatic human insulin, highlighting recombinant technology as a viable source.

Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin

Discussion

Member takes

Implication

Key Points

Cite This Study

Chemical, Physical, and Biologic Properties of Biosynthetic Human Insulin

Discussion

Member takes

Implication

Key Points

Cite This Study

Also Consider

Also Consider