Key result
The presence, number, or type of respiratory viruses were not associated with disease severity in hospitalized children with SARI, whereas prematurity and lower weight-for-age z-score predicted worse outcomes.
Why the study?
It was unknown whether the presence, number, or type of virus is associated with clinical outcomes of pediatric severe acute respiratory infection in developing countries.
Is the presence, number, or type of respiratory viruses associated with clinical outcomes in hospitalized children with severe acute respiratory infection?
Population
316 hospitalized children with SARI in Suriname
Comparison
Presence, number, or type of virus identified via multiplex PCR panel
Design
Two-year prospective surveillance study
Authors
Loading...
Viral testing should not guide severity assessment in pediatric SARI; leaves open whether prematurity and underweight status independently drive outcomes.
Observational (n=316)
No
Is the presence, number, or type of respiratory viruses associated with clinical outcomes in hospitalized children with severe acute respiratory infection?
p-value: p=0.365
In hospitalized children with severe acute respiratory infection in Suriname, clinical outcomes were driven by host factors like prematurity and underweight rather than the specific viral etiology.
Juliana et al. (2021) conducted an observational in Severe acute respiratory infection (SARI) (n=316). Viral infection (detected via PCR) vs. No viral infection was evaluated on Course of disease severity (mild, moderate, severe) (p=0.365). The presence, number, or type of respiratory viruses were not associated with disease severity in hospitalized children with SARI, whereas prematurity and lower weight-for-age z-score predicted worse outcomes.
Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context: