What is the clinical evidence from this study?

Study design: Cohort. Population: Severe acute respiratory infection (SARI) (n=370). Intervention: Respiratory viruses. Primary outcome: Detection of at least one respiratory virus (95% CI 91.4-96.8).

What question did this study set out to answer?

To determine the viral etiology and clinical characteristics of severe acute respiratory infection (SARI) in hospitalized pediatric patients during and following the 2009 H1N1 pandemic.

August 22, 2013PLoS ONEOpen Access

At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.

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Population

370 hospitalized children with severe acute respiratory infection in China from May 2008 to March 2010.

Design

Cohort

Key result

At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.

Authors

CZChen Zhang NZNa Zhu ZXZhengde Xie

Discussion

Member takes

Overview

May inform viral testing strategies in pediatric SARI; leaves open regional surveillance and intervention priorities.

Key Points

To determine the viral etiology and clinical characteristics of severe acute respiratory infection (SARI) in hospitalized pediatric patients during and following the 2009 H1N1 pandemic.
Enrolled a cohort of 370 hospitalized children aged 1 to 72 months with SARI in China between May 2008 and March 2010.
Tested nasopharyngeal aspirate specimens using a commercial multiplex assay targeting 18 respiratory viruses and analyzed associations with clinical profiles.
Respiratory viral pathogens were detected in 350 of 370 patients (94.29%), led by enterovirus/rhinovirus (54.05%), respiratory syncytial virus (51.08%), and human bocavirus (33.78%).
Pandemic H1N1 was the dominant influenza subtype but was present in only 20 children (5.41%).
Detection of respiratory syncytial virus and human metapneumovirus was significantly higher among suburban children than urban children (P < 0.05), accompanied by a higher incidence of viral SARI in suburban children aged 24 to 59 months (P < 0.05).

Study Design

Type

Cohort (n=370)

Multicenter

Structured PICO

Population

370 hospitalized children aged 1 to 93 months with severe acute respiratory infection in China, evaluated for viral etiology.

Outcome

Viral distribution and its association with clinical characteristics

Piconaviruses and paramyxoviruses are the most common viral pathogens among children with severe acute respiratory infections in China, with higher incidence of RSV and hMPV in suburban patients.

Limitations

Single-center study conducted at one hospital
Lack of a healthy control group to compare viral detection rates
Inability to definitively determine the clinical relevance of EV/RV single and coinfections on outcomes

Cite This Study

Zhang et al. (2013) conducted a cohort in Severe acute respiratory infection (SARI) (n=370). Respiratory viruses was evaluated on Detection of at least one respiratory virus (95% CI 91.4-96.8). At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.

synapsesocial.com/papers/6a98e87f0db9ef5c6f748ae8 https://doi.org/10.1371/journal.pone.0072606

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August 22, 2013PLoS ONEOpen Access

At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.

View Full Paper

Ask AI

Bookmark

Population

370 hospitalized children with severe acute respiratory infection in China from May 2008 to March 2010.

Design

Cohort

Key result

Authors

CZChen Zhang NZNa Zhu ZXZhengde Xie

Discussion

Member takes

Overview

May inform viral testing strategies in pediatric SARI; leaves open regional surveillance and intervention priorities.

Key Points

To determine the viral etiology and clinical characteristics of severe acute respiratory infection (SARI) in hospitalized pediatric patients during and following the 2009 H1N1 pandemic.
Enrolled a cohort of 370 hospitalized children aged 1 to 72 months with SARI in China between May 2008 and March 2010.
Tested nasopharyngeal aspirate specimens using a commercial multiplex assay targeting 18 respiratory viruses and analyzed associations with clinical profiles.
Respiratory viral pathogens were detected in 350 of 370 patients (94.29%), led by enterovirus/rhinovirus (54.05%), respiratory syncytial virus (51.08%), and human bocavirus (33.78%).
Pandemic H1N1 was the dominant influenza subtype but was present in only 20 children (5.41%).
Detection of respiratory syncytial virus and human metapneumovirus was significantly higher among suburban children than urban children (P < 0.05), accompanied by a higher incidence of viral SARI in suburban children aged 24 to 59 months (P < 0.05).

Study Design

Type

Cohort (n=370)

Multicenter

Structured PICO

Population

370 hospitalized children aged 1 to 93 months with severe acute respiratory infection in China, evaluated for viral etiology.

Outcome

Viral distribution and its association with clinical characteristics

Piconaviruses and paramyxoviruses are the most common viral pathogens among children with severe acute respiratory infections in China, with higher incidence of RSV and hMPV in suburban patients.

Limitations

Single-center study conducted at one hospital
Lack of a healthy control group to compare viral detection rates
Inability to definitively determine the clinical relevance of EV/RV single and coinfections on outcomes

Cite This Study

synapsesocial.com/papers/6a98e87f0db9ef5c6f748ae8 https://doi.org/10.1371/journal.pone.0072606

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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