Key result
At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.
Cohort (n=370)
No
Piconaviruses and paramyxoviruses are the most common viral pathogens among children with severe acute respiratory infections in China, with higher incidence of RSV and hMPV in suburban patients.
Answers are grounded in this paper and cite their sources.
May inform viral testing strategies in pediatric SARI; leaves open regional surveillance and intervention priorities.
BACKGROUND: No comprehensive analysis is available on the viral etiology and clinical characterization among children with severe acute respiratory infection (SARI) in China during 2009 H1N1 pandemic and post-pandemic period. METHODS: Cohort of 370 hospitalized children (1 to 72 months) with SARI from May 2008 to March 2010 was enrolled in this study. Nasopharyngeal aspirate (NPA) specimens were tested by a commercial assay for 18 respiratory viral targets. The viral distribution and its association with clinical character were statistically analyzed. RESULTS: Viral pathogen was detected in 350 (94.29%) of children with SARI. Overall, the most popular viruses were: enterovirus/rhinovirus (EV/RV) (54.05%), respiratory syncytial virus (RSV) (51.08%), human bocavirus (BoCA) (33.78%), human parainfluenzaviruse type 3 (PIV3) (15.41%), and adenovirus (ADV) (12.97%). Pandemic H1N1 was the dominant influenza virus (IFV) but was only detected in 20 (5.41%) of children. Moreover, detection rate of RSV and human metapneumovirus (hMPV) among suburb participants were significantly higher than that of urban area (P<0.05). Incidence of VSARI among suburb participants was also significant higher, especially among those of 24 to 59 months group (P<0.05). CONCLUSION: Piconaviruses (EV/RV) and paramyxoviruses are the most popular viral pathogens among children with SARI in this study. RSV and hMPV significantly increase the risk of SARI, especially in children younger than 24 months. Higher incidence of VSARI and more susceptibilities to RSV and hMPV infections were found in suburban patients.
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Zhang et al. (2013) conducted a cohort in Severe acute respiratory infection (SARI) (n=370). Respiratory viruses was evaluated on Detection of at least one respiratory virus (95% CI 91.4-96.8). At least one respiratory viral pathogen was detected in 94.29% of hospitalized children with severe acute respiratory infection, with enterovirus/rhinovirus and respiratory syncytial virus being the most common.
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