What is the clinical evidence from this study?

Study design: Observational. Population: Acute respiratory infections (ARIs) (n=1074). Intervention: Respiratory viruses vs. Virus-negative cases. Primary outcome: Viral detection rate.

March 12, 2015BMC Infectious DiseasesOpen Access

Among pediatric outpatients with acute respiratory infections in southern China, at least one respiratory virus was detected in 82.3% of cases, with multiple viruses found in 38.6%.

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Population

1,074 children presenting within 3 days of onset of illness with acute respiratory infections at outpatient…

Design

Cross-sectional

Key result

Among pediatric outpatients with acute respiratory infections in southern China, at least one respiratory virus was detected in 82.3% of cases, with multiple viruses found in 38.6%.

Authors

BCBinglin Cui DZDangui Zhang HPHui Pan

Discussion

Member takes

Overview

High viral detection and co-detection rates in pediatric ARI support expanded local surveillance; hypothesis-generating for meteorological associations.

Study Design

Type

Observational (n=1,074)

Multicenter

Structured PICO

Population

1,074 children aged 0-16 years presenting with acute respiratory infections at outpatient clinics in southern China over a one-year period.

Exposure

Multiplex real-time PCR detection of 14 respiratory viruses and correlation with meteorological factors (temperature, humidity, wind velocity).

Outcome

Viral detection rates, co-detection rates, and associations with meteorological factors and clinical presentations.

High viral detection and co-detection rates, primarily enterovirus and rhinovirus, were found in pediatric acute respiratory infections, with significant associations to meteorological factors like temperature and humidity.

Limitations

The majority of outpatients enrolled were mild and moderate cases, potentially missing pathogens responsible for severe ARIs.
Healthy or asymptomatic controls were not included, so viral carriage burdens and the actual role of virus infections could not be elucidated.
Lack of clinical follow-up and serologic testing.
Air quality indicators such as Ozone and PM2.5 were not included in the investigation of meteorological factors.
Difficulty interpreting multiplex PCR results due to detection of low amounts of viral nucleic acids during incubation, asymptomatic infection, or post-infectious shedding

Cite This Study

Cui et al. (2015) conducted an observational in Acute respiratory infections (ARIs) (n=1,074). Respiratory viruses vs. Virus-negative cases was evaluated on Viral detection rate. Among pediatric outpatients with acute respiratory infections in southern China, at least one respiratory virus was detected in 82.3% of cases, with multiple viruses found in 38.6%.

synapsesocial.com/papers/6a209261bb4ba07152cc48af https://doi.org/10.1186/s12879-015-0863-6

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March 12, 2015BMC Infectious DiseasesOpen Access

Among pediatric outpatients with acute respiratory infections in southern China, at least one respiratory virus was detected in 82.3% of cases, with multiple viruses found in 38.6%.

View Full Paper

Ask AI

Bookmark

Population

1,074 children presenting within 3 days of onset of illness with acute respiratory infections at outpatient…

Design

Cross-sectional

Key result

Among pediatric outpatients with acute respiratory infections in southern China, at least one respiratory virus was detected in 82.3% of cases, with multiple viruses found in 38.6%.

Authors

BCBinglin Cui DZDangui Zhang HPHui Pan

Discussion

Member takes

Overview

High viral detection and co-detection rates in pediatric ARI support expanded local surveillance; hypothesis-generating for meteorological associations.

Study Design

Type

Observational (n=1,074)

Multicenter

Structured PICO

Population

1,074 children aged 0-16 years presenting with acute respiratory infections at outpatient clinics in southern China over a one-year period.

Exposure

Multiplex real-time PCR detection of 14 respiratory viruses and correlation with meteorological factors (temperature, humidity, wind velocity).

Outcome

Viral detection rates, co-detection rates, and associations with meteorological factors and clinical presentations.

Limitations

The majority of outpatients enrolled were mild and moderate cases, potentially missing pathogens responsible for severe ARIs.
Healthy or asymptomatic controls were not included, so viral carriage burdens and the actual role of virus infections could not be elucidated.
Lack of clinical follow-up and serologic testing.
Air quality indicators such as Ozone and PM2.5 were not included in the investigation of meteorological factors.
Difficulty interpreting multiplex PCR results due to detection of low amounts of viral nucleic acids during incubation, asymptomatic infection, or post-infectious shedding

Cite This Study

synapsesocial.com/papers/6a209261bb4ba07152cc48af https://doi.org/10.1186/s12879-015-0863-6

Also Consider

Synapse has enriched 5 closely related papers on similar clinical questions. Consider them for comparative context:

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