Key result
This protocol outlines a planned systematic review and meta-analysis to evaluate whether superb microvascular imaging can accurately detect carotid plaque neovascularization.
Why the study?
Studies have yielded conflicting evidence on whether superb microvascular imaging can detect carotid plaque neovascularization with accuracy comparable to contrast-enhanced ultrasound.
Does Superb microvascular imaging (SMI) accurately detect intraplaque neovascularization in carotid plaque compared with contrast-enhanced ultrasound?
Meta-Analysis
Does Superb microvascular imaging (SMI) accurately detect intraplaque neovascularization in carotid plaque compared with contrast-enhanced ultrasound?
This protocol outlines a planned systematic review and meta-analysis to evaluate the diagnostic accuracy of Superb microvascular imaging compared to contrast-enhanced ultrasound for detecting carotid intraplaque neovascularization.
Does not yet support clinical use of superb microvascular imaging for carotid plaques; protocol leaves open diagnostic accuracy evaluation.
BACKGROUND: Superb microvascular imaging (SMI) is a novel Doppler technique that depicts low velocity blood flow without the use of a contrast agent. Studies suggested that SMI may or may not detect neovascularization of carotid plaque with accuracy comparable to contrast-enhanced ultrasound. To gain clarity, a meta-analysis to systematically review and synthesize relevant data on the SMI for the detection of intraplaque neovascularization was undertaken. METHODS: We will search PubMed, Web of Science, Cochrane Library, and Chinese biomedical databases from their inceptions to the June 31, 2020, without language restrictions. Two authors will independently carry out searching literature records, scanning titles and abstracts, full texts, collecting data, and assessing risk of bias. Review Manager 5.2 and Stata14.0 software will be used for data analysis. RESULTS: This systematic review will investigate whether SMI is feasible on the detection of intraplaque neovascularization compared with contrast-enhanced ultrasound. CONCLUSION: Its findings will provide helpful evidence for the feasibility of SMI on the detection of intraplaque neovascularization. SYSTEMATIC REVIEW REGISTRATION: INPLASY202070097.
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Zhou et al. (2020) conducted a meta-analysis in Carotid plaque neovascularization. Superb microvascular imaging (SMI) vs. Contrast-enhanced ultrasound was evaluated on Detection of intraplaque neovascularization. This protocol outlines a planned systematic review and meta-analysis to evaluate whether superb microvascular imaging can accurately detect carotid plaque neovascularization.
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