Key result
Superb microvascular imaging showed good consistency with contrast-enhanced ultrasonography for detecting intraplaque neovascularization (pooled Kappa 0.743; 95% CI 0.696-0.790; P<0.01).
Why the study?
This study was conducted to assess the consistency of superb microvascular imaging and contrast-enhanced ultrasonography in detecting intraplaque neovascularization.
Does superb microvascular imaging (SMI) show consistency with contrast-enhanced ultrasonography (CEUS) in detecting intraplaque neovascularization in carotid plaques?
Meta-Analysis (n=608)
Does superb microvascular imaging (SMI) show consistency with contrast-enhanced ultrasonography (CEUS) in detecting intraplaque neovascularization in carotid plaques?
Effect estimate: Kappa 0.743 (95% CI 0.696-0.790)
p-value: p=< 0.01
SMI ultrasound demonstrates good consistency with CEUS and may be a promising alternative for detecting intraplaque neovascularization in carotid plaques.
Supports SMI as contrast-free alternative for intraplaque neovascularization assessment; confirms diagnostic agreement with CEUS.
This meta-analysis assesses the consistency of superb microvascular imaging (SMI) and contrast-enhanced ultrasonography (CEUS) in detecting intraplaque neovascularization (IPN). We searched PubMed, Web of Science, the Cochrane Library, and CBM databases. A meta-analysis was conducted using STATA version 15.1 software. We calculated the pooled Kappa index. Ten studies that met all of the inclusion criteria were included in this meta-analysis. A total of 608 carotid plaques were assessed through both SMI and CEUS. The pooled summary Kappa index was 0.743 (95% confidence interval (CI) = 0.696-0.790) with statistical significance (z = 31.14, P < 0.01). We found no evidence of publication bias (t = -1.21, P = 0.261). Our meta-analysis indicates that SMI and CEUS display a good consistency in detecting the IPN of carotid plaque; that is, SMI ultrasound may be a promising alternative to CEUS for detecting the IPN of carotid plaque.
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Yang et al. (2020) conducted a meta-analysis in Intraplaque neovascularization of carotid plaque (n=608). Superb microvascular imaging (SMI) vs. Contrast-enhanced ultrasonography (CEUS) was evaluated on Consistency in detecting intraplaque neovascularization (pooled Kappa index) (Kappa 0.743, 95% CI 0.696-0.790, p=< 0.01). Superb microvascular imaging showed good consistency with contrast-enhanced ultrasonography for detecting intraplaque neovascularization (pooled Kappa 0.743; 95% CI 0.696-0.790; P<0.01).
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