Key result
A mutant influenza A virus with alterations to NP codons 464-466 replicated to around one-tenth the level of wild-type virus and packaged reduced levels of segments 3 and 5.
Population
Influenza A virus vRNA segments
Comparison
Synonymous mutations introduced into the… vs Wild type virus
Design
Preclinical
Authors
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May inform codon-based attenuation strategies for influenza vaccines; leaves open confirmation of segment packaging interactions in clinical strains.
Mutations in NP codons 464-466 of influenza A virus segment 5 reduce viral replication and packaging of segments 3 and 5, suggesting an interaction between these segments during viral assembly.
Hutchinson et al. (2009) studied Influenza A virus. Synonymous mutations in segment 5 vRNA (NP codons 464-466) vs. Wild type virus was evaluated on Replicative fitness and packaging levels. A mutant influenza A virus with alterations to NP codons 464-466 replicated to around one-tenth the level of wild-type virus and packaged reduced levels of segments 3 and 5.
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