Key result
Elastic modulus-based thrombelastographic analysis of tPA (0-300 U/ml) demonstrated significantly decreased onset, increased rate, and increased extent of fibrinolysis.
Population
In vitro plasma clot model
Design
Preclinical
Authors
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May aid laboratory fibrinolysis assessment; leaves open clinical translation.
An elastic modulus-based thrombelastographic approach can quantify the extent of fibrinolysis and the effects of pro- and anti-fibrinolytic agents in laboratory settings.
Nielsen et al. (2005) studied coagulopathy. tissue plasminogen activator (tPA) was evaluated on clot disintegration kinetics (onset, speed and extent of clot disintegration). Elastic modulus-based thrombelastographic analysis of tPA (0-300 U/ml) demonstrated significantly decreased onset, increased rate, and increased extent of fibrinolysis.
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