Key result
Gene transfer and cell therapy offer potential mechanisms for therapeutic angiogenesis in critical ischemic disease.
Why the study?
Therapeutic angiogenesis and vasculogenesis remain important options to induce vascular growth after critical ischemia despite ambiguous clinical trial results.
This review discusses the mechanisms and therapeutic potential of gene and cell therapy for inducing angiogenesis and vasculogenesis in ischemic disease.
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Sustains interest in gene and cell therapies for critical ischemia; leaves open definitive efficacy confirmation in randomized trials.
Losordo et al. (2004) conducted a review in Ischemic Disease. Therapeutic angiogenesis and vasculogenesis (gene and cell therapy) was evaluated. This review discusses the mechanisms of therapeutic angiogenesis and vasculogenesis, including gene transfer of proangiogenic factors and cell therapy, for treating critical ischemic disease.
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