Key result
Birth weight was inversely associated with adult heart failure risk (HR 0.83 per SD; 95% CI 0.76-0.90), while low birth weight combined with young adult overweight/obesity increased risk five-fold.
Why the study?
Heart failure hospitalizations among young adults and middle-aged individuals have increased, motivating an evaluation of birth weight and the transition from low birth weight to young adult overweight/obesity on adult heart failure risk.
Do birth weight and young adult BMI predict the risk of developing adult heart failure in men?
Cohort (n=35,659)
Do birth weight and young adult BMI predict the risk of developing adult heart failure in men?
Hazard Ratio: 0.83 (95% CI 0.76–0.9)
Low birth weight combined with overweight/obesity in young adulthood significantly increases the risk of developing heart failure in men, highlighting the importance of a life course perspective in risk assessment.
Supports life-course HF risk assessment in men; extends prior cohorts but leaves causal inference and intervention effects open.
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Bygdell et al. (2021) conducted a cohort in heart failure (n=35,659). Birth weight was evaluated on heart failure (HR 0.83, 95% CI 0.76-0.90). Birth weight was inversely associated with adult heart failure risk (HR 0.83 per SD; 95% CI 0.76-0.90), while low birth weight combined with young adult overweight/obesity increased risk five-fold.
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