Key result
Combined post/precapillary pulmonary hypertension due to left heart disease is associated with an unfavorable prognosis, and current evidence does not support the use of pulmonary arterial hypertension-specific therapies for these patients.
Why the study?
Pulmonary hypertension is a common complication of left heart diseases, and the combined post/precapillary subtype carries an unfavorable prognosis and high mortality.
Combined post- and pre-capillary pulmonary hypertension due to left heart disease is a distinct hemodynamic subtype associated with a worse prognosis, requiring careful diagnostic evaluation and cautious management.
Combined post/precapillary PH identifies higher-risk left heart disease patients; leaves open evidence-based therapies pending prospective data.
Рulmonary hypertension (PH) is a common complication of left heart diseases. In addition to a passive increase of pressure in the venous bed of the pulmonary circulation, leading to an increase of mean pulmonary pressure, signs of precapillary PH could be detected in some patients. Since 2013, a hemodynamic subtype of PH due to left heart diseases combined post/precapillary PH has been identified, with a more unfavorable prognosis and high mortality.
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Aleevskaya et al. (2020) conducted a review in Pulmonary hypertension due to left heart disease (combined post/precapillary PH). Combined post/precapillary pulmonary hypertension due to left heart disease is associated with an unfavorable prognosis, and current evidence does not support the use of pulmonary arterial hypertension-specific therapies for these patients.
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