Key result
Insulin therapy for 3 months significantly increased the corrected QT interval from 0.406 to 0.421 seconds (P=0.0025) in patients with type 2 diabetes.
Why the study?
Does medium-term insulin therapy increase corrected QT intervals in patients with type 2 diabetes?
Observational (n=17)
Does medium-term insulin therapy increase corrected QT intervals in patients with type 2 diabetes?
Absolute Event Rate: 0.421% vs 0.406%
p-value: p=0.0025
Medium-term insulin therapy significantly increased the corrected QT interval in a small cohort of patients with type 2 diabetes, highlighting a potential electrophysiological effect of insulin treatment.
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May warrant QTc monitoring with insulin in T2D; leaves open arrhythmic risk and requires randomized confirmation.
Kohzo Takebayashi (2012) conducted an observational in Type 2 diabetes (n=17). Insulin therapy vs. Baseline (before insulin therapy) was evaluated on Corrected QT intervals (QTc) (p=0.0025). Insulin therapy for 3 months significantly increased the corrected QT interval from 0.406 to 0.421 seconds (P=0.0025) in patients with type 2 diabetes.
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